CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. Four patients treated with CLO, who were smokers, were nonresponders and had low plasma levels while receiving usual doses. “No way!” said Dr. Lester. If you’ve decided to pull back on your caffeine intake for any reason, the first step is to figure out how much caffeine you’re actually consuming. From fighting off the common cold to preventing long term illness, a strong immune system is…, Proponents of cryotherapy claim it can help with weight loss, pain relief, and boosting athletic performance…, In the era of ‘treat yo’self’, focusing on nourishing yourself is a radical act of self-care.…, With so many supplements on the market these days, determining which are actually high quality, safe,…, Frequent urination or inability to control urination. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers. You have two copies of the CYP1A2 gene—one inherited from each of your parents—and each can be either a “fast” or “slow” version of the gene. Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. ultra-rapid metabolizer. It’s found mainly in the liver [1, 2]. Align your health hacks with your genes for optimal health & cognitive function. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. GET … The good news is that even if you’re a slow caffeine metabolizer, you can enjoy your morning coffee as long as you’re wise about your consumption. rs762551 (also known as -163C>A or CYP1A2*1F) is one of the best-studied SNPs in the CYP1A2 gene. Your caffeine levels peak about 1-hour after consumption and then start to decrease gradually. Based on your reaction to caffeinated beverages, you probably already have a hunch as to whether you’re a fast or slow caffeine metabolizer. Meanwhile, energy drinks can have anywhere from 60 to 250 mg of caffeine per serving. It is possible to have side effects even with a very low drug dose, because the enzyme is very slow to break down the drug. The enzyme is highly genetically polymorphic. Fast metabolizers of caffeine may have a high caffeine tolerance. On the other hand, studies suggest that slow metabolizers who drink coffee: It’s important to note that just because certain genotypes are associated with a disease, it doesn’t necessarily mean that everyone with that genotype will actually develop the disease. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. The good news is that once you balance your hormones with the help of a doctor, it’s likely you’ll be able to tolerate caffeine again. Cut down gradually by halving your intake every 3 days until you’re completely off any caffeine source,” she said. In the liver, it accounts for approximately 13% of all CYP enzymes . The information from animal studies is given solely for information purposes and will be updated as soon as new findings from human studies become available. In this case, opt for organic options or buy from companies that are transparent about the process they use. If you carry 1 or two "bad" copies of this gene, it will slow your ability to process your caffeine intake - and you may be more sensitive than someone else. So if you’re a slow caffeine metabolizer, should you be cutting out caffeine from your routine entirely? She's been featured in the New York Times, Marie Claire, Forbes, SELF, The Times, Huffington Post, and Travel + Leisure. There’s a gene that determines how caffeine impacts you. Let’s look at CYP1A2 in table 4. In particular, a study found an association between drinking coffee while young and lower risk of breast cancer in women who were CYP1A2 slow metabolizer and also carriers of the BRCA1 mutation [, Cigarette smoke: dose dependently, 1.72-fold for >20 cigarettes per day [, Coffee consumption: 1.45-fold per liter of coffee drunk daily [, Meat pan-fried at high temperatures: 1.4-fold [, Cruciferous vegetables, including broccoli, cabbage, Brussels sprouts, and cauliflower [, Apiaceous vegetables (carrots, parsnips, celery, and parsley) [, Kale ingestion, unlike that of other cruciferous vegetables [. One well known substrate of CYP1A2 is caffeine; individuals who carry one or more CYP1A2*1C alleles are "slow" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "fast" caffeine metabolizers. Procyshyn RM, Su J, Elbe D, Liu AY, Panenka WJ, Davidson J, Honer WG, Barr AM. We believe that the most accurate information is found directly in the scientific source. March 5, 2018 Shari Basch. Our goal is to not have a single piece of inaccurate information on this website. If you’re consuming more than that, it might be worth cutting down your caffeine intake, especially if you’re a slow caffeine metabolizer or are experiencing any of the side effects of too much caffeine listed above. Read on to find out more about this enzyme, and factors that can increase or decrease it. is a clickable link to peer-reviewed scientific studies. Baseline levels of the enzyme may be similar between the two, but ‘A’ is associated with higher “inducibility”, which means the enzyme becomes more active in the presence of inducers such as caffeine or cigarette smoke [14, 10, 15]. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. This means that those having the A/A genotype will process caffeine and other substances metabolized by CYP1A2 much quicker, and these substances will have less effect on the body. The enzyme CYP1A2 is responsible for metabolizing caffeine in the body and determines whether the individual is a slow or a fast caffeine metabolizer. SelfDecode allows you to dig deep inside your genetics and find the genes that may be underlying chronic health issues. Lower/undetectable plasma concentrations may increase probability of pharmacotherapy failure Select alternative drug not predominantly metabolized by CYP2D6 : Strong . J Clin Psychopharmacol. Note that ethnic differences exist in CYP2D6 activity. It is also the key enzyme responsible for metabolizing caffeine. CYP1A2 Ultrarapid metabolizer genotype . • The activity of CYP1A2 alleles is largely determined by environmental factors and genetic variability. CYP1A2: Caffeine tolerance. … Chris Kresser, LAc recently made an excellent review of how coffee can be good or bad for you based on whether you are a fast or slow metabolizer of caffeine. Join SelfHacked today and start the journey of improving your life. Even if you’re a fast caffeine metabolizer, you can still experience side effects of too much caffeine such as: According to Mayo Clinic, a healthy caffeine intake can be up to 400 milligrams (mg) a day. If you have two “fast” versions, you’re considered a fast caffeine metabolizer. More than 40 single nucleotide polymorphisms (SNPs) of the CYP1A2 gene have been discovered so far .African and Asian populations seem to have lower enzyme activity .rs762551 A/A is a fast metabolizer, while C/C and AC are slow metabolizers. In contrast, if you have one or two versions of the “slow” version of CYP1A2, you’re labeled a “slow” caffeine metabolizer, meaning you clear caffeine from your system about four times slower than your quick metabolizing counterparts, says Dr. Lester. The cytochrome P450 (CYP)1 enzyme debrisoquine 4-hydroxylase known as CYP2D6 is involved in the oxidative metabolism of many different classes of commonly used drugs, including neuroleptics, tricyclic antidepressants, selective serotonin reuptake inhibitors, β-adrenoceptor blockers, and antiarrhythmics (1)(2). A homozygous, that is, AA genotype represents individuals that can rapidly metabolize caffeine. Genetic variations in these enzymes may cause changes in their activity and result in differences in … Caffeine is the most common “drug” in the world and after water, coffee is the most popular beverage on earth. An enzyme called cytochrome P450 2C19 (CYP2C19 “Sip – 2 – See – 19”) helps to process some medications including clopidogrel (Plavix®), voriconazole (Vfend®), and … According to Dr. Lester, if you’re dependent on caffeine to function and get through the day—and you’re still tired even after getting plenty of sleep—it could be a sign that you have underlying adrenal fatigue. Are you worried about your pre-existing health problems? You can read more about CYPs and CYP metabolizer types here. The enzyme efficiency varies between individuals. More than 40 single nucleotide polymorphisms (SNPs) in the CYP1A2 gene have been discovered so far . Estrogen and caffeine are both broken down in the liver by the CYP1A2 enzyme. Cytochrome P450 (CYP) 2D6 and 1A2 are enzymes that metabolize many psychotropic medications. “Women that have estrogen dominance often do not have an abundance of this enzyme and therefore should not consume caffeine as they will also have a hard time detoxing it,” explained Dr. Lester. read more about CYPs and CYP metabolizer types here. HEAR FROM A REAL PATIENT. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. She believes that SelfHacked has the best science that is also layperson-friendly on the web. So, for example, someone with anxiety may not be able to tolerate an espresso but can happily drink a matcha latte!”. This CYP has only one functioning allele, which is inhibited by citalopram. Work with a doctor and health coach to uncover the root of your symptoms and start healing—completely free for 3 weeks. Some individuals have a mutation in this … This site uses Akismet to reduce spam. Help Protect Yourself From Illness and Viruses by Optimizing Your Health! Everyone seems to react to caffeine differently; some get jittery and anxious from a few sips of coffee while others can drink cup after cup without blinking an eye. Studies have found that fast metabolizers: A meta-analysis of 21 studies with over 10k people suggests that the ‘AA’ genotype may be associated with a higher risk of lung cancer, but a lower risk of bladder cancer . In the body, CYP1A2 accounts for around 95% of caffeine metabolism. And he zeroed in on one gene in particular, CYP1A2, which controls an enzyme – also called CYP1A2 – that determines how quickly our bodies break … Joe Cohen won the genetic lottery of bad genes. In the end, there’s no cut and dried equation for how much caffeine you should consume. Increased metabolism to less active compounds when comapred to extensive metabolizers. Atomoxetine (Strattera in the U.S.) is another drug significantly metabolized via CYP2D6. Watch a video about Shauna’s story. Caffeine acts as a natural stimulant and for this reason, the FDA has it listed as both a food and a drug. Hi, recently got some genetic testing done and most of my enzymes came back relatively normal, except for CYP1A2, for which I have the ultrarapid metabolizer genotype (-3860G>A - G/A, -2467T>DELT - T/DELT, -163C>A - C/A). She has a masters degree in physiology and complementary and alternative medicine from Georgetown University and is the former health editor at mindbodygreen. This could indicate an underlying health concern, such as estrogen dominance. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. “It usually comes up if a patient has done a 23andMe or other direct-to-consumer genetic test,” she continued. “In that case, cutting out caffeine entirely for a period may be the best option to discuss with your doctor,” she explained. You can also find herbal chai—made from rooibos or herbal tea instead of black tea—that tastes like your favorite chai without the stimulating effects. For example, an 8-ounce cup of coffee has about 95 to 200 mg of caffeine compared to a cup of green tea, which has about 14 to 60 mg in an 8-ounce serving. Caffeine is a bitter, white substance that’s found naturally in more than 60 different plants, including coffee beans, tea leaves, and kola nuts, which are used to make soda. These can increase CYP1A2 activity, according to human studies: These can increase CYP1A2 activity in animals: These can decrease CYP1A2 activity based on human studies: These can decrease CYP1A2 activity in animals: It’s important to stress that what’s found in animals, doesn’t always match what’s later found in humans. Genetic testing for CYP2D6 activity can be performed, but it is not yet a routine procedure. It is used primarily in children with ADD/ADHD, who are typically started at a low dose, then that dose is increased in increments until an effective dose is found for the child. The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. ultra-rapid metabolizer; extensive metabolizer; intermediate metabolizer ; poor metabolizer; As science and medicine progress, doctors can increasingly rely on genetics when it comes to diagnosis and treatment decisions. “I don’t typically test for CYP1A2 in isolation,” explained Dr. Lester. CYP1A2 activates cancer-causing agents such as aromatic heterocyclic amines, polycyclic aromatic hydrocarbons (PAHs), and aflatoxin B1 . The ultra-rapid metabolizer pheotype may be identified, but overlaps completely with the extensive metabolizers. You have two copies of the CYP1A2 gene—one inherited from each of your parents—and each can be either a “fast” or “slow” version of the gene. “A general rule is to go by halves. In a study of 717 seniors who drank a lot of coffee, rapid metabolizers tended to have a lower bone mineral density (BMD) than slow metabolizers . The enzyme CYP1A2 increasingly isinvolved in drug interactions as newmedications metabolized by thisenzyme are released. These are enzymes that eliminate most of the drugs and toxins from the human body . Caffeine can also be hiding in places you might not expect. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Turning to other caffeine-free drinks can help you ease the transition. People who have the ‘CC’ genotype of this SNP are rapid metabolizers (more active enzyme), while ‘CT’ and ‘TT’ genotypes are slow metabolizers (less active enzyme). Recently, researchers discovered these variations in caffeine tolerance can be traced back to genetic differences, which brings us to the CYP1A2 gene. We do not aim to diagnose, treat, cure or prevent any illness or disease. Individuals with two copies of the CYP2C19*17 polymorphism are typically classified as ultra-rapid metabolizers. Article PubMed Google Scholar 2. Boost your immune system by optimizing your entire body with a gene-based approach to your health. 5 Steps that May Regenerate the Liver Naturally, 3+ Promising Health Benefits of Tamarind + How to Eat It, Toxins, such as aromatic heterocyclic amines (in cigarette smoke, charbroiled meat), polycyclic aromatic hydrocarbons (in cigarette smoke, diesel exhaust, pollution), and aflatoxin, Are more likely to benefit from caffeine as an athletic performance booster [, Are less likely to develop high blood pressure (hypertension) and heart disease when they drink coffee [, May be at a higher risk of developing high blood pressure (hypertension) and heart disease when they drink coffee regularly [, May have a lower risk of breast cancer (women). These then need to be neutralized by other enzymes. Individual Genes Tested. The function of this CYP will likely be diminished to such a degree that the person will convert from an Intermediate Metabolizer into a Poor Metabolizer. The difference is not clinically significant. Posted by 12 months ago. CYP1A2 activity shows a remarkable degree of variation (up to 40-fold) between individuals based on their genes, ancestry, and environmental factors (e.g. She is passionate about releasing the most accurate science and health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. Apart from the liver, CYP1A2 has also been detected in the pancreas and lungs . CYP1A2 is an important detox enzyme that breaks down toxic chemicals, drugs, hormones, and other products of metabolism in order to eliminate them from your body. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. People with ‘AC’ and ‘CC’ genotypes (slow metabolizers) process caffeine and other substances metabolized by this enzyme more slowly, which is why they can have more of an effect on the body. Finally I’ve found a competent doctor who realizes what any specialist with nine years of medical training should know, that some people are simply rapid metabolizers of certain medications. Their plasma levels to dose ratios of CLO (median; range, 0.34; 0.22 to 0.40 ng × day/mL × mg) were significantly lower than ratios calculated from another study … Poor Metabolizer: A poor-metabolizing enzyme has very low activity. CYP1A2 Genetic Variants: One of the fun things to find out from your CYP1A2 genes is whether you are a fast or slow metabolizer of caffeine. Some people (ultra-rapid metabolizers) should not use Cerdelga because they break down the drug rapidly and may not benefit from it. CYP1A2 is an important enzyme that helps to break down toxins in our bodies. To get specific, caffeine targets the central nervous system and makes you feel more awake, energized, and alert. About 1.6 billion cups of coffee are consumed every single day worldwide; in other words, it’s deeply ingrained in our culture and our daily routine. Bishop JR, Pavuluri MN. You can find golden milk or turmeric lattes in many coffee shops and cafes and it is naturally caffeine-free. Caffeine is metabolized by a liver enzyme coded by the gene CYP1A2. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Your email address will not be published. It’s all about evaluating your relationship with caffeine and figuring out what’s best for your lifestyle and genetics. 1. This is because CYP1A2 turns the pro-carcinogenic molecules into carcinogens, which then have to be removed from the body. More specifically, it may depend on one gene—called CYP1A2—that determines how your body metabolizes the caffeine found in fan favorite beverages like tea, coffee, and soda. Review of risperidone … Note that each number in parentheses [1, 2, 3, etc.] As Dr. Lester explained, “Each of these beverages have different amounts of caffeine with tea being the lowest. Rapid or Ultrarapid Metabolizers: These enzymes are very active, often breaking down drugs before they can have any effect. This enzyme is one of the cytochrome P450 monooxygenases (CYPs). When you’re cutting back on caffeine, Dr. Lester recommends going slowly or you might experience caffeine withdrawal symptoms like headaches, irritability, and fatigue. “For someone like me who does have that genetic variant, I do not have caffeine after 8 a.m. otherwise it will be difficult for me to fall asleep at night,” she said. Kang YS(1), Park SY, Yim CH, Kwak HS, Gajendrarao P, Krishnamoorthy N, Yun SC, Lee KW, Han KO. A higher dose may also be required in order to reach the expected outcome of the medication. CYP1A2*1F has been associated in many studies with increased inducibility of CYP1A2 by, e.g ... slow and fast metabolizer phenotypes were reported based on the metabolism of the chemical carcinogen acetylaminofluorene in a panel of human liver microsomal preparations. It’s often described as a cognitive and physical performance enhancer. But proceed with some caution. Such people have two copies of the fast variant. You can test for the caffeine gene through a simple saliva or blood test that analyzes your DNA. Consider this case: Two patients each take the same dose of the same antidepressant medication. Among CYP1A2inducers, smoking is probably the mostimportant, but the usual enzyme inducerssuch as rifampin and barbituratescan also substantially i… Close. I’m a rapid metabolizer for dexedrine, and I’ll tell you, finding a doctor who’s willing to treat me with the doses I need has been a nightmare. Required fields are marked *. The same amount of caffeine will, therefore, tend to have more negative effects on CYP1A2 slow metabolizers. People with ‘AA’ genotype (fast metabolizers) processes caffeine and other substances metabolized by this gene much more quickly (when induced), and these substances will have less of an effect on their bodies. In fact, Dr. Lester is a slow caffeine metabolizer herself and still enjoys her daily dose of caffeine. Then, it provides recommendations that are personalized based on YOUR genes to give you superior results and help you achieve peak health so that your body is best prepared to defend itself from Coronavirus. This first variant is very well studied for the speed of caffeine metabolism. If you have two “fast” versions, you’re considered a fast caffeine metabolizer. Many different factors, including other genetic and environmental factors, can influence the risk of high blood pressure, heart disease, and cancer! The same amount of caffeine will therefore tend to have … There are two possible variants (alleles): ‘A’ and ‘C’. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. 4. Both increased and decreased CYP1A2 enzyme activity have been linked to increased risk of cancer [11, 12, 13]. The caffeine you ingest passes through the stomach and small intestine, entering the bloodstream in a little as 15 minutes. Ultra-rapid metabolizer : Paroxetine . Other Names for This Gene (R)-limonene 6-monooxygenase (S)-limonene 6-monooxygenase (S)-limonene 7-monooxygenase; CPCJ; CYP2C; CYPIIC17; CYPIIC19; cytochrome P-450 II C; cytochrome P450 2C19 precursor ; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), … Caffeine tolerance in an individual is gene deep. Talk to your doctor about starting Cerdelga. CYP2C9; CYP2C19; CYP2D6; CYP3A4 / CYP3A5; ADRA2A; CYP1A2; CYP2B6; CYP4F2 / VKORC1; COMT; DPYD; Factor II – Factor V Leiden; GRIK4; HLA … Not every beverage contains the same amount of caffeine. Here’s how to use it to your…. The most obvious choice is the caffeine-free version of your favorite coffee or tea-based beverage. Ultra-rapid metabolizer: 0.03 (0.02 to 0.06) Extensive metabolizer: 0.08 (0.04 to 0.17) Intermediate metabolizer: 0.56 (0.30 to 1.0) Poor metabolizer: 2.5 (1.8 to 4.1). Is caffeine bad for you? The speed of this decline depends on your CYP1A2 gene, which controls an enzyme (also called CYP1A2) that is in charge of breaking down any caffeine that enters the body. In addition, CYP1A2 variants have been associated with heart disease risk. Learn how your comment data is processed. For CYP2D6 and CYP3A4, similar problems arise concerning Citalopram. Although a R-to-9-OHR concentration ratio >1 generally indicates a poor metabolizer, it could also indicate the presence of a powerful CYP2D6 inhibitor. The genetics of CYP2D6 has been extensively studied, and individuals can be divided into 4 groups. An ancient Ayurvedic tradition, golden milk is a creamy, lightly sweet beverage that contains turmeric powder and steamed milk—and oftentimes honey and cinnamon, vanilla, and other spices. View now. According to Dr. Tiffany Lester, M.D., physician and medical director at Parsley Health San Francisco, “These are the people that can have an espresso and go right to sleep!”. Variations in the genes responsible for caffeine metabolism also affect how you respond to certain medicines. Studies suggest that African and Asian populations may have lower enzyme activity on average . The CYP1A2 gene made headlines a few years ago when a study, published in the Journal of the American Medical Association, showed that slow metabolizers who drink more than four cups of coffee per day have an increased risk for heart disease. The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density. Download our guide to find out how you can take your health into your own hands and create a regimen that is designed to keep your body as healthy as possible. Home Blog Patient How Being a Poor, Intermediate, Rapid, or Ultra Rapid Metabolizer can Impact Your Medication Outcomes. Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility. All of our content is written by scientists and people with a strong science background. Kombucha and chocolate are two hidden sources of caffeine that you might not be taking into account. Biljana received her PhD from Hokkaido University. Our website services, content, and products are for informational purposes only. People with the AA genotype at rs762551 (within the CYP1A2 gene) are “fast metabolizers” while those with the AC or CC are “slow metabolizers.” (6 and 7). Cytochrome P450 2C19 (CYP2C19) Ultrarapid Metabolizer. In addition to the wild-type gene (CYP2D61), at least 15 different alleles of CYP2D6, associated with deficient, reduced, normal, or increased enzyme activity, … The clinical response to the same dose of a drug may vary among individuals. Author information: (1)Department of Internal Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, … Cutting back on caffeine isn’t always easy. This enzyme is important for removing toxic chemicals from our body and processing hormones and other products of our metabolism. That said, knowing that she has this genetic variant has helped her consume caffeine more strategically. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. People respond differently to diets and supplements because everyone has a unique genetic code. most ultra-rapid CYP2D6 metabolizers. The CYP3A4*18 Genotype in the Cytochrome P450 3A4 Gene, a Rapid Metabolizer of Sex Steroids, Is Associated With Low Bone Mineral Density December 2008 Clinical Pharmacology & … You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. A patient who will metabolize a drug even faster than a rapid metabolizer and usually before the body is able to attain the desired effect. Many companies use harsh chemicals to remove caffeine that you’ll want to avoid. Clozapine (CLO), an atypical antipsychotic, depends mainly on cytochrome P450 1A2 (CYP1A2) for its metabolic clearance. Parsley Health's licensed and accredited medical experts use holistic medicine to heal you from the inside out. References. Heritability studies suggest that genetic variants may determine up to 75% of CYP1A2 enzyme activity, while food, supplements, and smoking are responsible for the rest [9, 10]. Patientswho are poor metabolizers (individuals with no CYP2D6 activity) or ultrarapid metabolizers (individuals with genetically elevated CYP2D6 activity) can have markedly altered response to drugs that are CYP2D6 substrates. Some of the substratesthat warrant particular attentionare theophylline, clozapine, olanzapine,and tizanidine. Instead, it’s up to you to be mindful and know how much caffeine is too much for your health and sleep quality. SelfHacked © 2013 – 2021 All Rights Reserved. Naturally caffeine-free options include herbal teas like chamomile, peppermint, rooibos, and hibiscus. CYP1A2 Ultrarapid metabolizer genotype. CYP1A2 is an inducible member of the cytochrome P450 (CYP) drug metabolizing gene family, important for metabolism of caffeine and antipsychotics. Gretchen Lidicker is a writer, researcher, and author of the book CBD Oil Everyday Secrets: A Lifestyle Guide To Hemp-Derived Health & Wellness. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. In other words, it doesn’t influence health in a significant enough way that she would go out of her way to order the test for every single one of her patients. It may depend on your genes. smoking, coffee consumption, and diet) [2, 3]. In this particular case, substances that affect CYP1A2 in animals are in some cases confirmed to have the same effect in humans, while in others they are shown to have no effect . Therefore variations in the CYP1A2 gene can have a big impact on how coffee will affect our bodies. This enzyme is activated via the aryl hydrocarbon receptor (Ahr) . Your email address will not be published. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Save my name, email, and website in this browser for the next time I comment. Parsley Health’s health coaches are experts in helping members determine what works best for them—and how to still enjoy caffeine if they choose.